Document Type

Patent

Patent Number

US Patent 7,776,344

Patent agency

United States Patent and Trademark Office

Publication Date

8-17-2010

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical GmbH (Düsseldorf, DE) ; Coley Pharmaceutical Group, Inc. (New York, NY, US)

Application Number

11/179,008

Date Filed

2005-07-08

Total Pages

89 pages

Abstract

Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.

Share

COinS
 

URL

https://ir.uiowa.edu/patents/518