US Patent 7,879,812
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR)9. Particular 4-5 base extensions at the 5′ and of the previously described core inhibitory ODN sequence enhances their inhibitory activity against human cells expressing human TLR9. Methods of use also are provided.
Ashman, Robert and Lenert, Petar Immunomodulatory oligonucleotides and methods of use therefor. US Patent 7,879,812 filed August 04, 2008 and issued February 01, 2011. https://ir.uiowa.edu/patents/530