Document Type

Patent

Patent Number

US Patent 7,879,812

Patent agency

United States Patent and Trademark Office

Publication Date

2-1-2011

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

12/185,418

Date Filed

2008-08-04

Total Pages

21 pages

Abstract

The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR)9. Particular 4-5 base extensions at the 5′ and of the previously described core inhibitory ODN sequence enhances their inhibitory activity against human cells expressing human TLR9. Methods of use also are provided.

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URL

https://ir.uiowa.edu/patents/530