US Patent 7,879,812
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR)9. Particular 4-5 base extensions at the 5′ and of the previously described core inhibitory ODN sequence enhances their inhibitory activity against human cells expressing human TLR9. Methods of use also are provided.
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Ashman, Robert and Lenert, Petar Immunomodulatory oligonucleotides and methods of use therefor. US Patent 7,879,812 filed August 04, 2008 and issued February 01, 2011. https://ir.uiowa.edu/patents/530