Document Type

Patent

Patent Number

US Patent 8,008,266

Patent agency

United States Patent and Trademark Office

Publication Date

8-30-2011

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US) ; Coley Pharmaceutical Group, Inc. (New York, NY, US)

Application Number

10/719,493

Date Filed

2003-11-21

Total Pages

74 pages

Abstract

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.

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URL

https://ir.uiowa.edu/patents/548