US Patent 8,008,266
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US) ; Coley Pharmaceutical Group, Inc. (New York, NY, US)
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
Krieg, Arthur M.; Steinberg, Alfred D.; and Klinman, Dennis Methods of treating cancer using immunostimulatory oligonucleotides. US Patent 8,008,266 filed November 21, 2003 and issued August 30, 2011. https://ir.uiowa.edu/patents/548