US Patent 8,058,249
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US) ; Coley Pharmaceutical Group, Inc. (New York, NY, US)
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
Krieg, Arthur M.; Kline, Joel; Klinman, Dennis; and Steinberg, Alfred D. Immunostimulatory nucleic acid molecules. US Patent 8,058,249 filed July 16, 2004 and issued November 15, 2011. https://ir.uiowa.edu/patents/551