Document Type


Patent Number

US Patent 8,114,848

Patent agency

United States Patent and Trademark Office

Publication Date



The United States of America as represented by the Department of Health and Human Services (Washington, DC, US) ; University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical Group, Inc. (New York, NY, US)

Application Number


Date Filed


Total Pages

24 pages


Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.

Creative Commons License

Creative Commons License
This work has been identified with a Creative Commons Public Domain Mark 1.0.