US Patent 8,119,766
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to increase functional glycosylation of α-dystroglycan in an affected tissue in the subject. Functional glycosylation is to be increased to an extent wherein the binding of α-dystroglycan to its ligands in the affected tissue is rescued to levels substantially similar to those in an evenly matched tissue unaffected by degeneration. One effective means for increasing functional glycosylation of α-dystroglycan in a subject includes increasing glycosyltransferase activity, such as LARGE or LARGE2 activity, in the muscle of the subject. Therapeutic glycosylated peptide compositions are also provided.
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Campbell, Kevin P and Barresi, Rita Increasing functional glycosylation of alpha-dystroglycan in the treatment of muscle degeneration. US Patent 8,119,766 filed June 02, 2005 and issued February 21, 2012. https://ir.uiowa.edu/patents/559