Document Type

Patent

Patent Number

US Patent 8,119,766

Patent agency

United States Patent and Trademark Office

Publication Date

2-21-2012

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

11/143,885

Date Filed

2005-06-02

Total Pages

35 pages

Abstract

Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to increase functional glycosylation of α-dystroglycan in an affected tissue in the subject. Functional glycosylation is to be increased to an extent wherein the binding of α-dystroglycan to its ligands in the affected tissue is rescued to levels substantially similar to those in an evenly matched tissue unaffected by degeneration. One effective means for increasing functional glycosylation of α-dystroglycan in a subject includes increasing glycosyltransferase activity, such as LARGE or LARGE2 activity, in the muscle of the subject. Therapeutic glycosylated peptide compositions are also provided.

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URL

https://ir.uiowa.edu/patents/559