US Patent 8,129,351
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical Group, Inc. (New York, NY, US) ; The United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, DC, US)
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
Krieg, Arthur M.; Klinman, Dennis; and Steinberg, Alfred D. Immunostimulatory nucleic acid molecules. US Patent 8,129,351 filed February 25, 2005 and issued March 06, 2012. https://ir.uiowa.edu/patents/563