US Patent 8,202,688
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical GmbH (Düsseldorf, DE) ; Ottawa Health Research Institute (Ottawa, CA)
The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
Davis, Heather L.; Schorr, Joachim; and Krieg, Arthur M. Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant. US Patent 8,202,688 filed November 20, 2002 and issued June 19, 2012. https://ir.uiowa.edu/patents/571