US Patent 8,258,106
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical Group, Inc. (New York, NY, US) ; The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US)
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
Krieg, Arthur M.; Kline, Joel N.; Klinman, Dennis; and Steinberg, Alfred D. Immunostimulatory nucleic acid molecules. US Patent 8,258,106 filed November 10, 2006 and issued September 04, 2012. https://ir.uiowa.edu/patents/581