US Patent 8,258,286
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
Davidson, Beverly L.; Mas Monteys, Alejandro; Mcbride, Jodi L.; and Boudreau, Ryan Reduction of off-target RNA interference toxicity. US Patent 8,258,286 filed May 29, 2008 and issued September 04, 2012. https://ir.uiowa.edu/patents/582