US Patent 8,282,918
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Disclosed are polynucleotides and polypeptides that are useful for assessing and modulating cell proliferation. The polynucleotides may comprise coding regions for RPA4 and RPA4/RPA32 hybrid polypeptides. The polynucleotides may be used in gene vectors for modulating cell proliferation in a patient in need thereof. Diagnostic methods related to assaying RPA4 expression in test samples in order to detect proliferating or cancerous cells also are disclosed.
Wold, Marc S. and Haring, Stuart J. Polynucleotides encoding RPA4/RPA32 hybrid polypeptides. US Patent 8,282,918 filed July 29, 2008 and issued October 09, 2012. https://ir.uiowa.edu/patents/584