Document Type

Patent

Patent Number

US Patent 8,309,738

Patent agency

United States Patent and Trademark Office

Publication Date

11-13-2012

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

12/685,014

Date Filed

2010-01-11

Total Pages

15 pages

Abstract

Methods for the preparation of indene-based thiazolidinethiones are provided comprising contacting 1-amino-2,3-dihydro-1H-inden-2-ol, or a substituted derivative thereof, with an acid under suitable reaction conditions to provide a first intermediate; and contacting the first intermediate with an alkali xanthate in the presence of an alkali hydroxide under suitable reaction conditions to provide a compound of formula (III), wherein R1-R8 are defined herein.

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URL

https://ir.uiowa.edu/patents/587