US Patent 8,524,881
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
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Davidson, Beverly L; Mas Monteys, Alejandro; Mcbride, Jodi L; and Boudreau, Ryan Reduction of off-target RNA interference toxicity. US Patent 8,524,881 filed July 18, 2012 and issued September 03, 2013. https://ir.uiowa.edu/patents/603