Document Type

Patent

Patent Number

US Patent 8,686,016

Patent agency

United States Patent and Trademark Office

Publication Date

4-1-2014

Assignee

The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC, US) ; University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

13/266,841

Date Filed

2010-04-30

Total Pages

42 pages

Abstract

Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.

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URL

https://ir.uiowa.edu/patents/616