US Patent 8,686,016
United States Patent and Trademark Office
The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC, US) ; University of Iowa Research Foundation (Iowa City, IA, US)
Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.
Reilly, Karlyne; Turbyville, Thomas; Beutler, John A.; and Wiemer, David Schweinfurthins and uses thereof. US Patent 8,686,016 filed April 30, 2010 and issued April 01, 2014. https://ir.uiowa.edu/patents/616