US Patent 9,063,118
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.
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Henry, Michael D and Barnes, Matthew J Isolation and characterization of tumor cells using shear stress measurements. US Patent 9,063,118 filed March 22, 2012 and issued June 23, 2015. https://ir.uiowa.edu/patents/638