US Patent 9,063,118
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.
Henry, Michael D. and Barnes, Matthew J. Isolation and characterization of tumor cells using shear stress measurements. US Patent 9,063,118 filed March 22, 2012 and issued June 23, 2015. https://ir.uiowa.edu/patents/638