Document Type

Patent

Patent Number

US Patent 9,090,701

Patent agency

United States Patent and Trademark Office

Publication Date

7-28-2015

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

13/605,341

Date Filed

2012-09-06

Total Pages

59 pages

Abstract

Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.

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URL

https://ir.uiowa.edu/patents/640