US Patent 9,249,100
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.
Quinn, Daniel M. and Topczewski, Joseph John Compounds and methods to treat organophosphorus poisoning. US Patent 9,249,100 filed January 24, 2014 and issued February 02, 2016. https://ir.uiowa.edu/patents/653