US Patent 9,272,016
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a sensitizing agent followed by contacting the cell with a therapeutic RNAi agent.
Mccray Jr., Paul B.; Davidson, Beverly L.; and Krishnamurthy, Sateesh Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells. US Patent 9,272,016 filed March 14, 2013 and issued March 01, 2016. https://ir.uiowa.edu/patents/657