US Patent 9,611,301
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America, as represented by the Department of Veterans Affairs (Washington, DC, US)
GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving GBV-C E2 polypeptides and peptides for use in modulating immune responses, including inhibition inflammation related to pathogenic T-cell activation.
Stapleton, Jack T.; Bhattarai, Nirjal; Xiang, Jinhua; and Mclinden, James H. GB virus C (hepatitis G virus) E2 glycoprotein as an immunomodulatory agent. US Patent 9,611,301 filed March 13, 2013 and issued April 04, 2017. https://ir.uiowa.edu/patents/685