US Patent 9,801,922
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Regents of the University of Michigan (Ann Arbor, MI, US)
The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.
Spitz, Douglas R.; Schultz, Michael K.; Kloepping, Kyle; Zhu, Yueming; Aykin-burns, Nukhet; and Wicha, Max S. Compositions and methods of treating cancer. US Patent 9,801,922 filed August 02, 2012 and issued October 31, 2017. https://ir.uiowa.edu/patents/697