US Patent 9,849,195
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner effective to infect an ependymal cell in the non-rodent mammal, wherein the ependymal cell secretes the therapeutic protein so as to treat the disease.
Davidson, Beverly L. Methods and compositions for treating brain diseases. US Patent 9,849,195 filed April 02, 2012 and issued December 26, 2017. https://ir.uiowa.edu/patents/701