US Patent 9,849,195
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner effective to infect an ependymal cell in the non-rodent mammal, wherein the ependymal cell secretes the therapeutic protein so as to treat the disease.
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Davidson, Beverly L Methods and compositions for treating brain diseases. US Patent 9,849,195 filed April 02, 2012 and issued December 26, 2017. https://ir.uiowa.edu/patents/701