Document Type

Patent

Patent Number

US Patent 9,849,195

Patent agency

United States Patent and Trademark Office

Publication Date

12-26-2017

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

14/008,994

Date Filed

2012-04-02

Total Pages

35 pages

Abstract

The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner effective to infect an ependymal cell in the non-rodent mammal, wherein the ependymal cell secretes the therapeutic protein so as to treat the disease.

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URL

https://ir.uiowa.edu/patents/701