Document Type

Patent

Patent Number

US Patent 9,884,052

Patent agency

United States Patent and Trademark Office

Publication Date

2-6-2018

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

14/951,106

Date Filed

2015-11-24

Total Pages

12 pages

Abstract

Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.

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URL

https://ir.uiowa.edu/patents/705