Inventor

Joseph A. Walder

Document Type

Patent

Patent Number

US Patent Re. 34,271

Patent agency

United States Patent and Trademark Office

Publication Date

6-1-1993

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

07/528,331

Date Filed

1990-05-24

Total Pages

13 pages

Abstract

A high yield method of production of a cross-linked hemoglobin derivative suitable for use as a blood substitute and plasma expander which is cross-linked between Lys 99 Alpha1 and Lys 99 Alpha2 in high percentage by adding the cross-linker in the presence of an added polyanion which blocks competing reactions at other sites of the protein.

Comments

Reissued. The portion of the term of this patent subsequent to July 15, 2003 has been disclaimed.

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URL

https://ir.uiowa.edu/patents/710