Document Type

Patent

Patent Number

US Patent Re. 41,461 E

Patent agency

United States Patent and Trademark Office

Publication Date

7-27-2010

Assignee

Massachusetts Institute of Technology (Cambridge, MA, US) ; University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

12/199,157

Date Filed

2008-08-27

Total Pages

20 pages

Abstract

A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Mono-clonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.

Comments

Reissued.

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URL

https://ir.uiowa.edu/patents/712