Document Type

Patent

Patent Number

US Patent Re. 43,472 E

Patent agency

United States Patent and Trademark Office

Publication Date

6-12-2012

Assignee

University of Medicine and Dentistry of New Jersey (Somerset, NJ, US) ; University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

12/604,840

Date Filed

2009-10-23

Total Pages

36 pages

Abstract

A novel isoform of tropomyosin is disclosed. The isoform is closely related to epithelial human tropomyosin (hTM) and more particularly to hTM5 except the last coding exon. The novel isoform, is called TC22. Northern blot analysis with TC22-specific probe revealed that normal culture cell lines and normal epithelial tissues expressed very little, if at all, TC22 message, whereas their transformed counterparts and tumor tissues including dysfunction of the alimentary canal, significantly increased the expression of TC22. Assays directed at determining the level of TC22 are useful in diagnostics and therapeutics of dysfunction of the alimentary canal. Specific antibodies and mimics for TC22 are also disclosed for use in diagnostics and therapeutics of dysfunction of the alimentary canal.

Comments

Reissued.

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URL

https://ir.uiowa.edu/patents/713