US Patent 4,916,219
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
There is disclosed oligosaccharide compounds having heparin-like anticomplement activity and reduced anticoagulant activity as compared with heparin on a weight or molar basis. The oligosaccharide compounds have at least 5 and no greater than 25 saccharide units. The oligosaccharides can have an even nuber of saccharide units with a terminus nonreducing sugar, or an odd number of saccharide units without a terminus nonreducing sugar. There is also disclosed anticomplement pharmaceutical compositions with reduced anticoagulant side effect activity and a process for preparing the oligosaccharide compounds.
Linhardt, Robert J. and Weiler, John M. Oligosaccharide heparin fragments as inhibitors of complement cascade. US Patent 4,916,219 filed August 02, 1988 and issued April 10, 1990. https://ir.uiowa.edu/patents/74