US Patent 4,975,447
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-hydroxyethoxy-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-hydroxyethoxy-2-benzothiazolesulfonamide compound.
Schoenwald, Ronald D. and Barfknecht, Charles F. 6-hydroxyethoxy-2-benzothiazolesulfonamide and topical treatment compositions and method for glaucoma. US Patent 4,975,447 filed April 04, 1985 and issued December 04, 1990. https://ir.uiowa.edu/patents/79