US Patent 4,975,449
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-chloro-benzothiazole-2-sulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-chloro-benzothiazole-2-sulfonamide compound.
Schoenwald, Ronald D. and Barfknecht, Charles F. Topical treatment of glaucoma with 2-benzothiazolesulfonamide derivative. US Patent 4,975,449 filed February 04, 1983 and issued December 04, 1990. https://ir.uiowa.edu/patents/81