US Patent 5,095,026
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Prodrugs are prepared of the carbonic anhydrase inhibitors 2-benzothiazolesulfonamide, hydroxymethazolamide, and dichlorphenamide. The prodrugs link a water soluble compound to the pharmacologically active carbonic anhydrase inhibitor through an enzymatically or hydrolytically degradable bond.
Schoenwald, Ronald D. and Barfknecht, Charles F. Prodrugs of carbonic anhydrase inhibitors. US Patent 5,095,026 filed September 22, 1989 and issued March 10, 1992. https://ir.uiowa.edu/patents/90