US Patent 5,157,044
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Analogs are prepared of the carbonic anhydrase inhibitors methazolamide, and dichlorphenamide. The analogs link a cleavable functional group to the pharmacologically active carbonic anhydrase inhibitor resulting in compounds of improved corneal permeability, which are non-irritable to the eye and which are effective topically to inhibit intraocular pressure.
Schoenwald, Ronald D. and Barfknecht, Charles F. Analogs of carbonic anhydrase inhibitors and their use as topical IOP inhibitors. US Patent 5,157,044 filed June 11, 1990 and issued October 20, 1992. https://ir.uiowa.edu/patents/97