Document Type

Article

Peer Reviewed

1

Publication Date

10-9-2013

NLM Title Abbreviation

PLoS One

Journal/Book/Conference Title

PLoS ONE

PubMed ID

24130802

DOI of Published Version

10.1371/journal.pone.0076889

Total Pages

15

Abstract

Comparative genome-wide expression profiling of malignant tumor counterparts across the human-mouse species barrier has a successful track record as a gene discovery tool in liver, breast, lung, prostate and other cancers, but has been largely neglected in studies on neoplasms of mature B-lymphocytes such as diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma (BL). We used global gene expression profiles of DLBCL-like tumors that arose spontaneously in Myc-transgenic C57BL/6 mice as a phylogenetically conserved filter for analyzing the human DLBCL transcriptome. The human and mouse lymphomas were found to have 60 concordantly deregulated genes in common, including 8 genes that Cox hazard regression analysis associated with overall survival in a published landmark dataset of DLBCL. Genetic network analysis of the 60 genes followed by biological validation studies indicate FOXM1 as a candidate DLBCL and BL gene, supporting a number of studies contending that FOXM1 is a therapeutic target in mature B cell tumors. Our findings demonstrate the value of the “mouse filter” for genomic studies of human B-lineage neoplasms for which a vast knowledge base already exists.

Keywords

OAfund

Journal Article Version

Version of Record

Published Article/Book Citation

PLoS ONE 8:10 (2013) pp. 1-15. doi:10.1371/journal.pone.0076889

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons 1.0 Public Domain Dedication.

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Pathology Commons

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URL

https://ir.uiowa.edu/pathology_pubs/2