Document Type

Article

Peer Reviewed

1

Publication Date

6-27-2016

NLM Title Abbreviation

Sci Rep

Journal/Book/Conference Title

Scientific Reports

PubMed ID

27346372

DOI of Published Version

10.1038/srep28484

Total Pages

10

Abstract

Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.

Keywords

OAfund

Comments

Sponsored by the Mayo Clinic Center for Individualized Medicine and the Mayo-Illinois Alliance for Technology Based Healthcare.

Journal Article Version

Version of Record

Published Article/Book Citation

Chen, J. et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci. Rep. 6, 28484; doi: 10.1038/srep28484 (2016).

Rights

Copyright © 2016 the authors

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Included in

Pathology Commons

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URL

https://ir.uiowa.edu/pathology_pubs/6