Document Type
Article
Publication Date
7-1-2018
NLM Title Abbreviation
Open Forum Infect Dis
Journal/Book/Conference Title
Open Forum Infectious Diseases
PubMed ID
30038931
DOI of Published Version
10.1093/ofid/ofy164
Start Page
164
End Page
164
Abstract
Group B Streptococcus (GBS) is a perinatal pathogen and an emerging cause of disease in adults. Culture-independent GBS detection relies on polymerase chain reaction (PCR) of conserved genes, including sip. We demonstrate suboptimal sensitivity of the existing sip PCR strategy and validate an improved method based on consensus sequences from >100 GBS genomes.
Keywords
Streptococcus, GBS, PCR, Pediatrics, sip, Pregnancy
Journal Article Version
Version of Record
Published Article/Book Citation
Open Forum Infect Dis. 2018 Jul 7;5(7):ofy164. doi: 10.1093/ofid/ofy164. eCollection 2018 Jul.
Rights
© The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Infectious Disease Commons, Medical Genetics Commons, Obstetrics and Gynecology Commons, Pathology Commons, Pediatrics Commons
URL
https://ir.uiowa.edu/pediatrics_pubs/18
Comments
This work was supported by the Doris Duke Charitable Foundation (DDCF CSDA 2009–039 to A.J.R.) and the National Institutes of Health (R33 AI098654 to A.J.R.; K23 HD065844 and R21 AI127957 to T.M.R.). M.G. and E.S. were supported by the Jack Cary Eichenbaum Neonatology Scholars Program at New York University School of Medicine.