Document Type

Article

Publication Date

7-1-2018

NLM Title Abbreviation

Open Forum Infect Dis

Journal/Book/Conference Title

Open Forum Infectious Diseases

PubMed ID

30038931

DOI of Published Version

10.1093/ofid/ofy164

Start Page

164

End Page

164

Abstract

Group B Streptococcus (GBS) is a perinatal pathogen and an emerging cause of disease in adults. Culture-independent GBS detection relies on polymerase chain reaction (PCR) of conserved genes, including sip. We demonstrate suboptimal sensitivity of the existing sip PCR strategy and validate an improved method based on consensus sequences from >100 GBS genomes.

Keywords

Streptococcus, GBS, PCR, Pediatrics, sip, Pregnancy

Comments

This work was supported by the Doris Duke Charitable Foundation (DDCF CSDA 2009–039 to A.J.R.) and the National Institutes of Health (R33 AI098654 to A.J.R.; K23 HD065844 and R21 AI127957 to T.M.R.). M.G. and E.S. were supported by the Jack Cary Eichenbaum Neonatology Scholars Program at New York University School of Medicine.

Journal Article Version

Version of Record

Published Article/Book Citation

Open Forum Infect Dis. 2018 Jul 7;5(7):ofy164. doi: 10.1093/ofid/ofy164. eCollection 2018 Jul.

Rights

© The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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URL

https://ir.uiowa.edu/pediatrics_pubs/18