NLM Title Abbreviation
Journal of perinatology : official journal of the California Perinatal Association
DOI of Published Version
OBJECTIVE: To evaluate if mid-pregnancy immune and growth-related molecular factors predict preterm birth (PTB) with and without (±) preeclampsia.
STUDY DESIGN: Included were 400 women with singleton deliveries in California in 2009-2010 (200 PTB and 200 term) divided into training and testing samples at a 2:1 ratio. Sixty-three markers were tested in 15-20 serum samples using multiplex technology. Linear discriminate analysis was used to create a discriminate function. Model performance was assessed using area under the receiver operating characteristic curve (AUC).
RESULTS: Twenty-five serum biomarkers along with maternal age80% of women with PTB ± preeclampsia with best performance in women with preterm preeclampsia (AUC = 0.889, 95% confidence interval (0.822-0.959) training; 0.883 (0.804-0.963) testing).
CONCLUSION: Together with maternal age and poverty status, mid-pregnancy immune and growth factors reliably identified most women who went on to have a PTB ± preeclampsia.
preeclampsia, obstetrics, preterm birth, pediatrics, growth-factor, biomarker testing
Journal Article Version
Version of Record
Published Article/Book Citation
Jelliffe-Pawlowski, L.L., Rand, L., Bedell, B., Baer, R.J., Oltman, S.P., Norton, M.E., Shaw, G.M., Stevenson, D.K., Murray, J.C., Ryckman, K.K. Prediction of preterm birth with and without preeclampsia using mid-pregnancy immune and growth-related molecular factors and maternal characteristics (2018) Journal of Perinatology, 38 (8), pp. 963-972. https://doi.org/10.1038/s41372-018-0112-0
© Nature America, Inc., part of Springer Nature 2018
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