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DOI of Published Version
BACKGROUND: Hemophilia A animal models have helped advance our understanding of factor VIII deficiency. Previously, factor VIII deficient mouse models were reported to have a normal life span without spontaneous bleeds. However, the bleeding frequency and survival in these animals has not been thoroughly evaluated.
OBJECTIVE: To investigate the survival and lethal bleeding frequency in two strains of E-16 hemophilia A mice.
METHODS: We prospectively studied factor VIII deficient hemizygous affected males (n = 83) and homozygous affected females (n = 55) for survival and bleeding frequency. Animals were evaluated for presence and location of bleeds as potential cause of death.
RESULTS AND CONCLUSIONS: Hemophilia A mice had a median survival of 254 days, which is significantly shortened compared to wild type controls (p < 0.0001). In addition, the hemophilia A mice experienced hemorrhage in several tissues. This previously-underappreciated shortened survival in the hemophilia A murine model provides new outcomes for investigation of therapeutics and also reflects the shortened lifespan of patients if left untreated.
OAfund, Hemophilia, Hemorrhage
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Staber JM, Pollpeter MJ (2016) Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model. PLoS ONE 11(5): e0154857. doi:10.1371/journal.pone.0154857
Copyright © 2016 Staber, Pollpeter
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This work is licensed under a Creative Commons Attribution 4.0 License.