Document Type


Peer Reviewed


Publication Date


NLM Title Abbreviation

PLoS One

Journal/Book/Conference Title

PLoS One

PubMed ID


DOI of Published Version


Start Page


Total Pages



INTRODUCTION: Immediate success rates of renal transplantation (RT) procedures are generally very high. National estimates of the impact of post-operative complications, specifically, septicemia occurring during hospitalization for RT's on outcomes is unclear. We sought, to examine the prevalence of septicemia in patients having renal transplantation procedures and to quantify the impact of septicemia on in-hospital mortality (IHM), length of stay (LOS), and hospital charges (HC).

MATERIALS AND METHODS: We performed a retrospective analysis of the Nationwide Inpatient Sample (NIS) for the years 2004 to 2010. All patients aged ≥18 years who underwent RT were selected. Association between occurrence of septicemia and outcomes (IHM, HC and LOS) was examined by multivariable linear and logistic regression models with adjustments for patient and hospital level confounders.

RESULTS: During the study period, 113,058 patients underwent RT, and, of these, 2459 (2.2%) developed septicemia. Characteristics included mean age (50 years), gender (males, 60%) and race (whites, 54%). Majority of RT's were performed in teaching (96%) and large institutes (85.5%). Outcomes for patients with septicemia and without septicemia, included: IHM (12.9% vs. 0.4%), discharge routinely (42.4% vs. 82.6%), mean HC ($528,980 vs. $182,165), mean LOS in days (35.2 vs 7.3), respectively, Those who developed septicemia were associated with significantly higher HC (estimate: 0.8357, 95% CI: {0.7636-0.9077}, increase of $ 247,081 from mean, p

CONCLUSIONS: Despite advances in medical/surgical care, septicemia is not an uncommon complication in patients having renal transplantation procedures and is associated with poor outcomes. Increasing age and co-morbid burden are independent predictors of occurrence of septicemia.


OAfund, Adult, Aged, Female, Hospital Mortality, Economics, Hospitalization, Humans, Kidney Transplantation, Length of Stay, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Outcome Assessment (Health Care), Postoperative Complications, Prevalence, Retrospective Studies, Sepsis, United States

Journal Article Version

Version of Record

Published Article/Book Citation

PLoS ONE12(6): e0179466.


Copyright: © 2017 Allareddy et al.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.