Mutations of the p53 tumor suppressor gene are associated with large differences (>7 vessels/HPF) in Microvessel density (MVD) counts between primary and metastatic tumor sites in patients with epithelial ovarian cancer. These data are consistent with models demonstrating p53 mutation functions directly to influence angiogenesis. This information supports continued therapy and research involving angiogenesis inhibitors in patients with ovarian cancer, especially in the setting of increased differences in MVD between primary and metastatic sites.
vascularity, P53, gene mutations, metastatic disease, epithelial, ovarian cancer
Copyright © 2011 Janna Girardi, Megan Samuelson, Anna Button, Koen De Geest, David P. Bender, Amina Ahmed, Michael J. Goodheart.
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Girardi J, Samuelson M, Button A, De Geest K, Bender DP, Ahmed A, Goodheart M. The relationship between vascularity, p53 gene mutations and distant metastatic disease in epithelial ovarian carcinoma. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 11 [2 p.]. https://doi.org/10.17077/2154-4751.1109. Free full text article.