Wnt/b-catenin signaling appears to be important in a multitude of cancers. This review article details current knowledge of the Wnt/b-catenin/Lef1 pathway in generalized gland regulation and formation in addition to endometrial cancer. Wnt signaling is critical for the development of the female urogenital system, in particular mullerian duct formation. Dysregulation of this signaling pathway at multiple nodes has been observed in numerous tumor types, including endometrial cancer. In particular, nuclear accumulation of b-catenin correlates with tumor severity. As such, therapeutic modulation of Wnt signaling represents an emerging avenue for the treatment of cancers that rely on this pathway.
beta Catenin, cancer, Lymphoid Enhancer-Binding Factor 1, neoplasms, uterus, Wnt proteins
Copyright © Dawne N. Shelton, Michael J. Goodheart, 2011.
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Shelton DN, Goodheart MJ. Wnt/ß-catenin/Lef-1 signaling in the uterus and its implications in uterine gland formation and cancer development. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 16 [11 p.]. https://doi.org/10.17077/2154-4751.1113. Free full text article.