Serous uterine endometrial cancer is a lethal disease for which new therapeutic regimens are urgently needed. Combinations of chemotherapeutic agents and small molecule growth factor inhibitors have demonstrated activity in cancers from other sites. Our objective was to determine whether such a combination using Paclitaxel and Gefitinib could be active in serous endometrial cancer cells.
Paclitaxel, Gefitinib, endometrial cancer, mitotic catastrophe, p38, p53
Copyright © Xiangbing Meng, Laura L. Laidler, Lina Albitar, Anna M. Holmes, Donghai Dai, Thomas E. Buekers, David P. Bender, Kimberly K. Leslie, 2011.
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Meng X, Laidler LL, Albitar L, Holmes AM, Dai D, Buekers TE, Bender DP, Leslie KK. The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 4 [2 p.]. https://doi.org/10.17077/2154-4751.1099. Free full text article.