Follicle-Stimulating Hormone (FSH) drops rapidly in pregnancy but Anti-Mullerian Hormone (AMH) has not been shown to drop until about 12 weeks. Since the follicles that secrete AMH are thought to be FSH independent, AMH levels should slowly decline in the absence of FSH because when the follicles reach FSH dependence, they would die off. A study has presented data that suggests a decline in AMH levels suddenly starts at 12 weeks gestation. The present study agrees with a decline in AMH after the first trimester. There is a sharp decline in AMH at 12-16 weeks gestation indicating that the follicular development is actively suppressed, not passively lost because of a drop in FSH. It appears that pregnancy may be a unique situation in regards to AMH.
Anti-Müllerian hormones, pregnancy
Copyright © Kelin Schultz, Barbara Stegman, Mark Santillan, Donna Santillan, Elaine Smith, Bradley J. Van Voorhis, 2012.
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Schultz K, Stegmann B, Santillan M, Santillan D, Smith E, Van Voorhis BJ. Anti-Müllerian Hormone concentration levels in maternal plasma during the first, second and third trimester of pregnancy. Proc Obstet Gynecol. 2012 May 15;2(3):Article 2 [2 p.]. https://doi.org/10.17077/2154-4751.1095. Free full text article.
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