Patients with hereditary retinoblastoma are at increased risk for second malignancies, most notably sarcomas, particularly after treatment with radiation. Malignant phyllodes tumor is a rare secondary malignancy in these patients. We present a review of the literature and report of a patient with hereditary retinoblastoma who developed two secondary malignancies, including malignant phyllodes tumor. The patient’s phyllodes tumor presented as a palpable breast mass with suspicious findings on mammogram and ultrasound. The mass was shown to be at least a borderline phyllodes tumor via sonographic percutaneous biopsy and confirmed malignant phyllodes tumor on final surgical excision.
retinoblastoma, phyllodes, leiomyosarcoma, breast neoplasms
The authors report no conflict of interest.
Copyright © Damon D. Shearer, Ryan W. Askeland, Jeong Mi Park, Laurie L. Fajardo, Limin Yang, 2013.
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Shearer DD, Askeland RW, Park JM, Fajardo LL, Yang L. Malignant phyllodes tumor in a patient with hereditary retinoblastoma: a case report and literature review. Proc Obstet Gynecol. 2013 Jul 03;3(2):Article 5 [9 p.]. https://doi.org/10.17077/2154-4751.1194. Free full text article.