Pregnant women who are obese are more likely to have gestational diabetes, gestational hypertension, pre-eclampsia, macrosomia, operative vaginal delivery, and cesarean delivery. Obesity also has adverse implications for the neonate. Congenital anomalies are more common in children born to obese women. These include neural tube defects, gastroschisis, cardiovascular anomalies, and others. Although the connection between maternal obesity and chronic health conditions has been described, the mechanism by which this occurs is less well understood. Changes to the epigenetic structure of offspring DNA have been proposed as one such mechanism.
DNA methylation, obesity, respiratory distress syndrome, pregnancy, diabetes, maternal, gestational, fetal
Copyright © 2015 Karla N. Solheim, Donna A. Santillan, Sabrina Scroggins, Eric J. Devor, and Mark K. Santillan
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Solheim KN, Santillan DA, Scroggins S, Devor EJ, Santillan MK. Global fetal DNA methylation and birth outcomes in obese women. Proc Obstet Gynecol. 2015 Feb 23;4(3):Article 12 [2 p.]. https://doi.org/10.17077/2154-4751.1268. Free full text article.