Granulosa cell tumors (GCT), a malignant type of sex-cord stromal tumor, account for approximately 2-5% of all ovarian malignancies. They are often identified before they have spread beyond the ovary, but advanced disease can be quite challenging to treat. Wnt signaling has been suggested to contribute to the formation of GCT. We hypothesized Wnt signaling was involved in human GCT.
Granulosa cell tumor, ovarian neoplasms, Wnt signaling
Copyright © 2015 Brian M. Kilonzo, Traci Neff, Megan I. Samuelson, and Michael J. Goodheart
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Kilonzo BM, Neff T, Samuelson MI, Goodheart MJ. Wnt signaling in granulosa cell tumors of the ovary. Proc Obstet Gynecol. 2015 Feb 23;4(3):Article 14 [1 p.]. https://doi.org/10.17077/2154-4751.1270. Free full text article.