For a successful pregnancy to occur, foreign genetic material such as the allogeneic fetus must be tolerated within the maternal host. Indoleamine 2,3-dioxygenase (IDO) is an enzyme induced by pro-inflammatory cytokines that has been shown to be key to this process. Obesity as a pro-inflammatory state is associated with poor obstetric outcomes. The primary objective of this study is to investigate the relationship between obesity and IDO activity.
Preeclampsia, obesity in pregnancy, immunology of pregnancy, fetal tolerance
The authors report no conflict of interest.
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Tyler EM, Santillan DA, Scroggins SM, Devor EJ, Hamilton WS, Hunter SK, Santillan MK. The relationship between obesity, pregnancy, and levels of indoleamine 2,3-dioxygenase. Proc Obstet Gynecol. 2016 Jan 20;5(3):Article 8 [2 p.]. https://doi.org/10.17077/2154-4751.1301. Free full text article.