High-grade serous ovarian cancer (HGSOC) is the most common and also the most aggressive subtype of ovarian cancer while squamous cell carcinoma (SCC) of the colon is an extremely rare histologic subtype of all colonic malignancies with poor prognosis.
Here we report a unique case of synchronous primary SCC of the colon and second recurrence of HGSOC in a patient with 15-years survival. Our patient developed two recurrent HGSOCs with disease-free survival time of five and nine years, respectively. The second recurrence of HGSOC was associated with the synchronous primary SCC of the ascending colon and was further complicated with the patient′s development of platinum resistance. Awareness of this unusual occurrence should emphasize the need for adequate sampling of tumor tissue in patients with relapsing ovarian cancer. Reports of more cases of SCC of the colon would possibly help to establish appropriate management modality and strategies for treatment.
High-grade serous ovarian cancer (HGSOC), recurrence, squamous cell carcinoma (SCC) of the colon, immunohistochemistry, treatment
The authors report no conflict of interest.
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Sladoljev K, Perin E, Ferrari AM, Klarić M, Brnčić-Fischer A, Eminović S, Vrdoljak-Mozetič D, Babarovic E. Relapsed ovarian high-grade serous carcinoma with long-term survival associated with synchronous primary squamous cell carcinoma of the colon. Proc Obstet Gynecol. 2018 Sep 12;8(2):Article 6 [9 p.]. . Free full text article.