Preeclampsia (PE) is characterized by late pregnancy hypertension and proteinuria. PE causes significant morbidity for the maternal-fetal unit. Circulating endothelin-1 (ET-1), a potent vasoconstrictor, is elevated at the time of diagnosis of human PE. In addition, women with PE demonstrate arterial stiffness as early as the end of the first trimester. However, it is unknown if arterial stiffness is associated with a first trimester elevation in ET-1 and post-delivery placental ET-1. We hypothesized that 1) first trimester plasma ET-1 is elevated and is associated with arterial stiffness in women who develop PE; 2) first trimester ET-1 is predictive of PE; and 3) placental ET-1 is increased in PE. To address these questions, we performed a nested case-control study in women at risk for PE
ET-1, endothelin-1, arterial stiffness, preeclampsia
The authors report no conflict of interest
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Betz AM, Pierce GL, Santillan DA, Devor EJ, Scroggins SM, Brandt DS, Stroud AK, Thomas KM, Holwerda SW, O’Deen A, DuBose LE, Grobe JL, Sigmund CD, Santillan MK. First trimester elevation in circulating endothelin-1 and arterial stiffness are predictive of late pregnancy preeclampsia. Proc Obstet Gynecol. 2018 Oct 29;8(3):Article 18 [2 p.]. . Free full text article.