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Authors

Alexandria M. Betz, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA
Gary L. Pierce, Department of Health and Human Physiology, University of Iowa, Iowa City, IA
Donna A. Santillan, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IAFollow
Eric J. Devor, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IAFollow
Sabrina M. Scroggins, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA
Debra S. Brandt, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IAFollow
Amy K. Stroud, Department of Health and Human Physiology, University of Iowa, Iowa City, IA
Kellie M. Thomas, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA
Seth W. Holwerda, Department of Health and Human Physiology, University of Iowa, Iowa City, IA
Allison O’Deen, Department of Health and Human Physiology, University of Iowa, Iowa City, IA
Lyndsey E. DuBose, Department of Health and Human Physiology, University of Iowa, Iowa City, IA
Justin L. Grobe, Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA
Curt D. Sigmund, Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA
Mark K. Santillan, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IAFollow

Abstract

Preeclampsia (PE) is characterized by late pregnancy hypertension and proteinuria. PE causes significant morbidity for the maternal-fetal unit. Circulating endothelin-1 (ET-1), a potent vasoconstrictor, is elevated at the time of diagnosis of human PE. In addition, women with PE demonstrate arterial stiffness as early as the end of the first trimester. However, it is unknown if arterial stiffness is associated with a first trimester elevation in ET-1 and post-delivery placental ET-1. We hypothesized that 1) first trimester plasma ET-1 is elevated and is associated with arterial stiffness in women who develop PE; 2) first trimester ET-1 is predictive of PE; and 3) placental ET-1 is increased in PE. To address these questions, we performed a nested case-control study in women at risk for PE

Keywords

ET-1, endothelin-1, arterial stiffness, preeclampsia

Total Pages

2

Financial Disclosure

The authors report no conflict of interest

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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