The concept that persistent feto-placental intolerance is important in the pathogenesis of preeclampsia (PE) has been demonstrated by our lab and others. Arginine vasopressin (AVP) infusion during pregnancy induces cardiovascular, renal, and immune alterations in mice consistent with human PE. These findings identify AVP as a potential contributor to poor fetal tolerance and the development of PE. In addition to their conventional immuno-stimulatory role, dendritic cells (DCs) also play a vital role in immune tolerance. In contrast to conventional DCs, regulatory DCs (DCregs) express low levels of co-stimulatory markers, produce anti-inflammatory cytokines, induce T regulatory cells, and promote tolerance. In mice, DCregs are able to prevent pro-inflammatory responses and induce antigen-specific tolerance. Given these known functions of DCregs, we hypothesize that DCregs will prevent the development of AVP-induced PE.
Dendritic cell, preeclampsia, arginine vasopressin
The authors report no conflict of interest.
Copyright © The authors, 2018.
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Scroggins SM, Santillan DA, Sandgren JA, Pierce GL, Sigmund CD, Grobe JL, Santillan MK. Regulatory dendritic cell treatment prevents the development of vasopressin-induced preeclampsia. Proc Obstet Gynecol. 2018 Oct 29;8(3):Article 20 [2 p.]. https://doi.org/10.17077/2154-4751.1433. Free full text article.