We have previously shown that maternal plasma copeptin (CPP), as a marker of vasopressin, is highly predictive of preeclampsia (PE) in the first trimester and remains elevated throughout pregnancy. Furthermore, in maternal urine samples we demonstrated that CPP was also significantly elevated in the first trimester in women who later developed PE. Because a urine dipstick test could be easily used in the clinic, we sought to validate this finding in a new and expanded cohort of samples and to determine whether these changes persist throughout pregnancy. In addition, to begin to address the mechanism for this difference, we also assessed urine osmolality to further probe renal function.
Osmolality, copeptin, arginine vasopressin, preeclampsia
The authors report no conflict of interest.
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Santillan DA, Scroggins SM, Ray AT, Zhang SY, Sigmund CD, Pierce GL, Grobe JL, Santillan MK. Static urine osmolality with elevated first trimester urine copeptin in human preeclampsia. Proc Obstet Gynecol. 2018 Oct 29;8(3):Article 22 [2 p.]. . Free full text article.