Background: Atypical hemolytic uremic syndrome (aHUS) may present in either the antepartum or postpartum period and is often indistinguishable from other pregnancy-associated diseases. Timely recognition and appropriate treatment can greatly reduce maternal morbidity and mortality.
Cases: This case series describes two cases of aHUS in the post-partum period, the difficulty in distinguishing the diagnosis, and the implementation of appropriate treatment with eculizumab, a terminal complement inhibitor.
Conclusion: As a terminal complement inhibitor, eculizumab, has been shown to significantly improve clinical and long term renal outcomes, early diagnosis of aHUS is increasingly important. These two cases of aHUS demonstrate the path of accurate diagnosis and timely initiation of therapy to maximize the possibility of patient recovery.
Atypical hemolytic uremic syndrome; pregnancy complications; renal disease; maternal morbidity
The authors report no conflict of interest
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Mattson J, Sheng JS, Leslie KK. Atypical hemolytic uremic syndrome in the postpartum period: a case series. Proc Obstet Gynecol. 2019 Aug 29;9(1):Article 3 [10 p.]. https://doi.org/10.17077/2154-4751.1402. Free full text article.