For patients with endometrial cancer at increased risk of perioperative morbidity, primary radiation therapy is an effective alternative treatment option. However, there has been no consensus on radiation technique and little data on outcomes. Our aim was to identify factors which determine patient selection for primary radiation, investigate treatment efficacy of radiation compared to surgical management of endometrial cancer and to evaluate different radiation modalities including external beam radiation therapy alone or with a boost of either high dose rate brachytherapy or intensity-modulated radiation therapy for differences in toxicities, recurrence-free interval, cancer-specific survival and overall survival.
Endometrial cancer, radiation, brachytherapy, intensity-modulated radiation therapy, obesity
The authors report no conflict of interest.
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Wagner VM, Salinas EA, Mott SL, Sun W, Goodheart MJ. Primary radiation as initial management in endometrial cancer: investigating EBRT, IMRT and HDR brachytherapy. Proc Obstet Gynecol. 2020 May 14;9(3):Article 14 [2 p.]. . Free full text article.